Is methylation important?

Some of the toughest patients will not get effective lowering of homocysteine until choline is supplemented. Choline converts to betaine with the help of riboflavin, vitamin B2, and aids methylation in this step of the pathway. TMG (trimethylglycine) provides extra methyl groups. Betaine with the help of B2 can convert back to glycine and aid the synthesis of creatine for muscle health. All needed nutrients have been included in Methylation Essentials for optimal results as well as magnesium and zinc which are cofactors for enzymes in the pathway.

Why so much emphasis on converting homocysteine back to methionine?

Many doctors don't realize that the most common block in the homocysteine pathway is the conversion of cystathionine to cysteine which requires B6 to activate the cystathionine beta-synthase enzyme, making B6 an important ingredient in Methylation Essentials. B6 is also required in the step that converts homocysteine into cystathionine. Serine, another important ingredient in Methylation Essentials, is needed in this step as well. Remember this part of the pathway synthesizes cysteine needed for glutathione synthesis and taurine which has multiple functions including preventing catabolism due to chronic stress and aiding insulin function, both being important for our metabolic syndrome patients.  Methylation Essentials, which includes all needed nutrients and cofactors, will work no matter where the patient's block in the pathway is because of the synergism of the ingredients, and will work in patients with the faulty genotype because of the high dose of folate and folinic acid it contains. This formula (by supplying folates and methylcobalamin B12) does aid the process for homocysteine to be converted back to methionine in case the body is in need of converting methionine into SAMe (S-adenosylmethionine) which is known to improve depression, neurotransmitters and support joint comfort, function and mobility in the spine, hips and knees. It is important to the joints because of its critical role in cartilage production. 

Bottom Line:

 Synergistic nutrients, found in Methylation Essentials, facilitate the homocysteine pathway, preventing toxic levels of homocysteine from accumulating, and make it possible for a functioning pathway to provide necessary methyl and sulfur groups for a myriad of biochemical reactions, especially those needed for detoxification, immune system support, joint and cartilage repair, brain health and for reducing our risk of cardiovascular and other serious diseases.

Suggested Use: take 2 caps daily with meals